About OvPlex™

What is the OvPlex™ Diagnostic?

OvPlex™ is a superior performing alternative to CA125 for the diagnostic process to check for ovarian cancer.

OvPlex™ is a diagnostic test that measures levels of four proteins in a patient’s blood. One of the proteins is CA125, which has been used for several years for the detection and monitoring of ovarian cancer. When measured along with the three additional proteins that make up OvPlex™, a significant enhancement in diagnostic performance can be achieved.

• OvPlex™ is a new multimarker blood test for ovarian cancer
• OvPlex™ is a superior performing alternative to CA125 alone
• OvPlex™ measures four blood borne biomarkers associated with ovarian cancer:

The multimarker test results are processed using an algorithm to generate a single OvPlex™ value which represents the likelihood that a woman has ovarian cancer

In addition to the OvPlex™ value, traditional CA125 values are also provided for reference

Independent statistical analysis has determined that OvPlex™ displays superior sensitivity (95.6%) and specificity (92.2%) compared with CA125 alone

OvPlex™ reduces the false negative rate by up to 50% and the false positive rate by 25% compared with using CA125 alone

OvPlex™ uses the minimally invasive methodology required by a simple blood test

Click here to view OvPlex™ data

Based upon the analysis of Receiver Operator Characteristic (ROC) Curves, OvPlex™ significantly out performs the CA125 blood test, for both early and late stage disease. For the detection of ovarian cancer overall, OvPlex™ delivers 92.2% specificity, 95.6% sensitivity and an overall diagnostic efficiency of 92.7%. OvPlex™ reduces the false negative rate by up to 50% and the false positive rate by 25% compared with using CA125 alone. The enhanced performance of OvPlex™, particularly with respect to detection of early stage ovarian cancers suggests that it will provide significant benefits in terms of diagnostic performance over the use of CA125 alone.

The Benefits

• Displays better diagnostic performance than CA125 alone, both for the detection of early and late stage ovarian cancer. At a threshold of 0.45, OvPlex™ displays, 95.6% sensitivity and 92.2% specificity.
• Displays better diagnostic performance than CA125 alone, both for the detection of early and late stage ovarian cancer. At a threshold of 0.45,
• May improve the detection of ovarian cancer. At equivalent specificity with CA125, OvPlex™ delivers 97% sensitivityvPlex™ displays, 95.6% sensitivity and 92.2% specificity.
• May reduce the false negative rate of CA125 by up to ~50% and the false positive rate by up to 25%.
• Traditional CA125 values are also provided for reference

What to do next?

Steps to follow

1. Order an OvPlex™ ovarian cancer test kit from Healthscope Pathology.

2. Take the kit including the enclosed request form to your doctor.
Please note: If you are taking any anti-inflammatory medications please discuss with your doctor as you will be required to stop taking this medication(s) for 5 days prior to specimen collection *. Fasting is not required for these tests.

3. Collection of blood samples.

$200 (no Medicare or private health fund rebate is currently available).

A collection fee of $30 will be charged if you attend another pathology provider other than Healthscope Pathology.
NB: Pathology providers other than Healthscope Pathology may in some cases charge an additional fee.

Testing cannot proceed without full payment of the kit.

Results will be forwarded to your doctor within 10-20 working days.

Order a kit online